MARS
Overview
The Minority Aging Research Study (MARS) is a longitudinal, epidemiological cohort study of decline in cognitive function and risk of Alzheimer’s disease in older African-Americans.
MARS began in 2004 and over 600 persons have enrolled, 560 of which are currently alive.
The study enrolls African-American men and women over age 65 that haven’t been diagnosed with dementia. After consent is obtained, a baseline evaluation is scheduled and performed in the participant’s home. At the baseline visit, a uniform, structured clinical evaluation is completed consisting of an interview to ascertain a variety of lifestyle and experiential risk factors, a neurological examination, a blood draw, and a comprehensive neuropsychological battery of 23 cognitive tests. The clinical evaluation is repeated on an annual basis. The autopsy program is offered to all subjects as well but not required. Participants also have yearly blood draws which result in the storage of serum, plasma and cells.
ICS' Role
MARS is a legacy project for the ICS group. The project's data needs were established before the ICS group ever existed.
ICS continues to provide daily EPIC/Clarity and custom Department of Neurology data-sourced data extracts to somewhere. Please see the automation page for more technical data details.
More Information
- The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) MARS Project Description
- WUSM: Department of Neurology: Knight Alzheimer Disease Research Center
- PubMed: Current Alzheimer Research: The Minority Aging Research Study: Ongoing Efforts to Obtain Brain Donation in African Americans without Dementia
- Rush University: Minority Aging Research Study
Contacts
Internal
| Name | Role |
|---|---|
| Warren Thomas | DBA |
| Snehil Gupta | Technical Lead |
External
| Name | Role | Contact Info |
|---|---|---|
| Karen Klumpp | Coordinator | kklumpp@wustl.edu |
| Joel Perlmutter | PI | perlmutterjoel@wustl.edu |
| Luke Page | Epic One Support | Marion.Page@bjc.org |
| Dan Kelly | Analyst | NA |
Project Management
Major Tasks & Initiatives
- Data Warehousing Billable Epic: MARS
- Data Warehousing Tasks: Migrate Mars to Databricks
- Data Brokerage Billable Epic 5621: Perlmutter - MARS Data Project
Important Dates & Notes
Important Deadlines
Currently None Scheduled
Deliverables
No specific deliverables yet
Meetings
| Name | Occurrence | Frequency | Teams Chat |
|---|
Administrative Details
Tracking Time
Please ensure all work involving the MARS project categorized underneath the following:
| Tracking Time Attribute | Value |
|---|---|
| Infra/Maintenance/Automation | Infrastructure/Maintenance |
| PM/Other support | MARS |
IRB
IRB #: 201811066
Title: Clincal Outcomes for Movement Disorders
PI: Joel Perlmutter
No. of approved subjects: 15500 Summary/abstract (Protocol Section 1.3): This is a chart review of clinical data on patients who have a movement disorder diagnosis including parkinsonism, tremor, dystonia, ataxia, chorea, myoclonus or other movement disorders. The aim of this study is to monitor the response to medications and treatments in the management for these diagnosis.
Digital Landmarks
Project Web Pages
- Is there a main project web page?
Document Repositories
- Box shared folder 1339: Perlmutter - MARS Data Project
- Are there any files in sharepoint?
Miscellaneous Meeting Notes
InfoSec Report
Not Applicable
Code Repositories
Technical Information
Guides, Tutorials, & References
Team Specific Documentation
Glossary / Acronyms
| Term | Definition |
|---|---|
| MARS | The Minority Aging Research Study |